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作者报道了成年C57BL/6J小鼠妊娠第12.5天受到分别为0,0.106,0.15G,0.312,0.518和0.658Gy60Coγ射线一次性全身照射对其仔代生后生长发育及行为的影响.研究发现:0.518Gy即可使仔鼠宫内体重发育受阻,0.106~3.518Gy则可使仔鼠生后的3~21天龄期间表现出体重增长增加;而生理标志、新生反射和感觉功能以及行为指标的检测,则提示生长发育受阻、行为兴奋性增加的致畸阈值在0.156~0.312Gy范围内.
The authors reported that adult C57BL / 6J mice received a one-time whole body irradiation of 0, 0.106, 0.15G, 0.312, 0.518 and 0.658Gy60Co gamma rays on day 12.5 of their pregnancy Effects of growth and behavior. The study found that: 0.518Gy intrauterine weight development can be obstructed offspring, 0.106 ~ 3.518Gy can make the pups born after 3 to 21 days of age showed an increase in body weight gain; and physiological markers, neonatal reflex And sensory function as well as behavioral indicators, suggesting that growth retardation, increased excitability behavior teratogenic threshold in the range of 0.156 ~ 0.312Gy.