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艾滋病病毒感染相关性肺动脉高压(HIV-PAH)是艾滋病病毒(HIV)感染者的非感染性并发症之一,发病率约为0.5%,发病机制尚不清楚,可能与HIV包膜蛋白和遗传易感性有关。HIV-PAH肺组织病理改变与特发性肺动脉高压(IPAH)相似,丛原性病变最为常见。临床表现缺乏特异性,最常见的症状为进行性呼吸困难,治疗主要包括抗肺动脉高压和抗逆转录治疗。HIV-PAH是HIV感染者死亡的独立危险因素,当HIV感染者出现不能解释的与心肺相关症状时,应考虑到HIV-PAH。
HIV-PAH is one of the non-infectious complications of HIV infection. The incidence rate is about 0.5%. The pathogenesis of HIV-PAH is not yet clear, which may be related to the HIV envelope protein and genetic Susceptibility related. Pathological changes in lung tissue of HIV-PAH Similar to idiopathic pulmonary hypertension (IPAH), the most common form of plexiform lesions. Clinical manifestations of the lack of specificity, the most common symptoms of progressive dyspnea, the treatment includes anti-pulmonary hypertension and antiretroviral therapy. HIV-PAH is an independent risk factor for the death of HIV-infected individuals and HIV-PAH should be considered when unexplained cardiopulmonary-related symptoms occur in HIV-infected individuals.