The synthesis and characterization of a series of metal porphyrins, M II (Por), {Por = dianionic of 5,10,15,20 tetrakis[4 (4’ bromobutyloxy)phenyl]porphyrinato and 5,10,15,20 tetrakis[4 (4’ butyloxypyridine bromide)phenyl] porphyrinato, M = Zn, Cu, Mn, Co, Ni, Ru CO} were described. The complexes 3a 3e were prepared from the reactions of compound 2 with metal acetates in chloroform, and the treatment of 3a 3f with excess of pyridine gave corresponding complexes 4a 4f. These new compounds were identified by absorption spectroscopies, 1H NMR and elemental analyses. The results of biological activity testing for 4a 4f revealed that 4a and 4c had stronger inhibiting action on the growth metabolism of Esche richia coli. The synthesis and characterization of a series of metal porphyrins, M II (Por), {Por = dianionic of 5,10,15,20 tetrakis [4 (bromobutyloxy) phenyl] porphyrinato and 5,10,15,20 tetrakis [ 4 (4 ’butyloxypyridine bromide) phenyl] porphyrinato, M = Zn, Cu, Mn, Co, Ni, RuCO} were described. The complexes 3a 3e were prepared from the reactions of compound 2 with metal acetates in chloroform, and the treatment of 3a 3f with excess of pyridine corresponding complexes 4a 4f. These new compounds were identified by absorption spectroscopies, 1H NMR and elemental analyzes. The results of biological activity testing for 4a 4f revealed that 4a and 4c had stronger inhibiting action on the growth metabolism of Esche richia coli.