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目的研究吴茱萸-木瓜药对配伍的最佳提取条件。方法首先进行提取条件的单因素考察,然后用多指标活动水平的正交设计法,将吴茱萸碱、吴茱萸次碱、总黄酮的提取率和干膏率作为评价指标,考察提取的乙醇浓度、溶剂用量、提取时间和提取次数等因素。结果吴茱萸-木瓜药对的配伍提取最佳工艺为55%乙醇回流提取两次,第1次加12倍量提取50 min,第2次加4倍量提取30 min。结论木瓜对吴茱萸有效成分提取有影响。经过优选的吴茱萸-木瓜药对配伍提取工艺,为其治疗痛风病的物质基础及作用机制研究奠定了基础。
Objective To study the optimum extraction conditions of Evodia-papaya on compatibility. Methods The single factor investigation of extraction conditions was carried out firstly. Then, the evidentiality indexes of evodiamine, rutaecarpine, total flavonoids and dry matter were used as the evaluation indexes by the orthogonal design method of multi-index activity level. The concentrations of ethanol, Dosage, extraction time and extraction times and other factors. Results The optimal extraction process of Fructus Evodiae-Papaya was 55% ethanol reflux extraction, the first 12-fold extraction for 50 min, the second plus 4-fold extraction for 30 min. Conclusion Papaya has an effect on the extraction of active ingredients of Evodia rutaecarpa. After the preferred Evodia - papaya medicine compatibility extraction process for the treatment of gout material basis and mechanism of action laid the foundation.