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目的 :观察输血后丙型肝炎病毒 (HCV)感染者的远期预后 ,调查 HCV感染后慢性形成的危险因素。方法 :用贝克曼 CX5全自动生化分析仪 ,对 88例输血后丙型肝炎 (PT- HC)患者血清进行肝功能检测 ;以 EL ISA法检测抗 - HCV及 HBVM;以荧光定量 PCR诊断试剂盒检测 HCV- RNA。结果 :输血后 10年丙氨酸转氨酶 (AL T)异常率 4 2 .0 5 % ,抗 - HCV阳性率 94 .32 % ,HCV- RNA阳性率 6 3.6 3%。 5 6例 HCV - RNA阳性者中 ,2 6例 AL T正常、抗- HCV阳性。 88例 PT- HC中转为慢性肝炎者 5 4例 ,失代偿性肝硬化 2例 ,转慢率 6 3.6 3% ,男性与女性转慢率为75 .0 0 %及 5 2 .2 7% ,P <0 .0 5 ;饮酒者与无饮酒史者的转慢率为 90 .0 0 %及 5 5 .88% ,P <0 .0 1。结论 :AL T异常是慢性 HCV感染者的一个重要特征 ,抗 - HCV是反映慢性 HCV感染者的一个较稳定的指标 ,HCV - RNA阳性的AL T正常者 ,可以认为系病后病毒携带者 ,PT- HC易转为慢性 ,男性及饮酒者为慢性形成的高危因素
Objective: To observe the long-term prognosis of patients with hepatitis C virus (HCV) infection after transfusion and to investigate the risk factors of chronic infection after HCV infection. Methods: The serum of 88 patients with hepatitis C (PT-HC) after transfusion was tested for liver function by Beckman CX5 automatic biochemical analyzer. The anti-HCV and HBVM were detected by ELISA. HCV-RNA was detected. Results: The ALT abnormality rate was 42.05% at 10 years after transfusion, the positive rate of anti-HCV was 94.32%, and the positive rate of HCV-RNA was 6 3.6 3%. Among 56 cases of HCV - RNA positive, 26 cases of ALT were normal and anti - HCV positive. Of the 88 patients with PT-HC, 54 were converted to chronic hepatitis, 2 were decompensated cirrhosis, with a slowing rate of 6 3.6 3%, and 75.0% with 52.27% , P <0.05. The rate of slowdown between drinkers and non-drinkers was 90.0% and 5.58%, P <0.01. CONCLUSIONS: ALT abnormalities are an important feature of chronic HCV infection. Anti-HCV is a more stable indicator of chronic HCV infection. HCV-RNA positive patients with normal ALT can be considered as carriers of post-infection virus, PT-HC easy to chronic, men and drinkers are risk factors for chronic formation