【摘 要】
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CLINICAL EVIDENCE REGARDING INTERLEUKIN(IL)-1BrnPeriodontitis is an inflammatory disease that infects tooth supporting tissue and eventually induces tooth loss.
【机 构】
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State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China
论文部分内容阅读
CLINICAL EVIDENCE REGARDING INTERLEUKIN(IL)-1BrnPeriodontitis is an inflammatory disease that infects tooth supporting tissue and eventually induces tooth loss. At present, the aetiology of periodontitis is characterised by both dysbiosis of the host and oral microbiota.1 Various mediators affect the balance in chronic inflammation. The pro-inflammatory cytokines include IL-1β, tumour necrosis factor (TNF)-α, IL-6 and IL-17, which lead to periodontal inflammation and tissue injury. Another group includes regulatory cytokines such as IL-10.2-3 IL-1β is a strong stimulator of periodontal tissue destruction.
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