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本实验将乙脑减毒活疫苗ＳＡ_（１４）－１４－２株以不同疫苗病毒量（３．８７ＰＦＵ／ｍｌ和５．８７ＰＦＵ／ｍｌ）分别一次免疫豚鼠，观察其对强毒攻击后抑制毒血症和抗体形成的能力。结果显示疫苗（５．８７ＰＦＵ／ｍｌ）免疫组豚鼠攻击前虽然中和抗体阴性或很低，但经攻击感染后不同时间内均未出现病毒血症，对照组豚鼠则于第２，３，４天全部出现病毒血症。表明一次活疫苗免疫后能有效地抑制病毒血症的产生。免疫后３０天虽然免疫组的豚鼠中和抗体很低，但攻击感染后抗体迅速增长。第四天的抗体滴度为１：８～３２，第５天达１：１２８～２５６，第１４天抗体高达１：５１２～１０２４；而对照组抗体则上升很慢，第７天才出现低水平抗体（１：４）。血凝抑制抗体增长的动态与中和抗体近似。表明活疫苗免疫后虽然中和抗体水平不高，但一经感染可迅速产生高滴度抗体达到保护作用。
In this experiment, guinea pigs were immunized once with different doses of vaccine virus (3.87PFU / ml and 5.87PFU / ml), respectively, against SA_ (14) -14-2 live attenuated JE vaccine. Blood disorders and the ability of antibodies to form. The results showed that the vaccines (5.87 PFU / ml) immunized group of guinea pigs before vaccination, although the neutralizing antibody was negative or very low, but no viremia was observed in different time after challenge and the guinea pigs in control group were All viremia day. It shows that a live vaccine can effectively inhibit viremia after immunization. Although the guinea pig neutralizing antibody in the immunized group was low at 30 days after immunization, the antibody rapidly increased after challenge with the infection. On the fourth day, the antibody titers ranged from 1: 8 to 32, reached 1: 128 to 256 on the 5th day, and from 1: 512 to 1024 on the 14th day. However, the antibody in the control group rose slowly and showed a low level on the 7th day Antibody (1: 4). The kinetics of hemagglutination inhibition antibody growth is similar to the neutralization antibody. It shows that although the level of neutralizing antibody is not high after the live vaccine is immunized, the high titers can be rapidly produced after infection to achieve the protective effect.