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为了探讨胰岛素样生长因子１在自发性高血压大鼠体内的改变与自发性高血压发生发展的病理生理过程中的关系，用放射免疫分析法测定正常和自发性高血压大鼠血浆和组织中胰岛素样生长因子－１含量。结果发现，自发性高血压大鼠心肌组织中胰岛素样生长因子－１含量显著增加（Ｐ＜０．０５），血浆中含量略有增加（Ｐ＞０．０５），而肝脏中的含量则显著降低（Ｐ＜０．０５）；两组大鼠体内均以肝脏中的胰岛素样生长因子－１含量最高。提示这些改变可能与心脏中胰岛素样生长因子－１在高血压及其心脏病变时异常增高有关。
To investigate the relationship between insulin-like growth factor-1 in spontaneous hypertensive rats and the pathophysiological process of spontaneous hypertension, radioimmunoassay was used to determine the plasma and tissue in normal and spontaneously hypertensive rats In insulin-like growth factor-1 content. The results showed that the content of insulin-like growth factor-1 in myocardium of spontaneously hypertensive rats increased significantly (P <0.05), the content of plasma increased slightly (P> 0.05), while the content of liver increased significantly (P <0.05). The contents of insulin-like growth factor-1 in the liver were the highest in both groups. Suggesting that these changes may be related to the abnormal increase of insulin-like growth factor-1 in heart during hypertension and heart disease.