The discovery of COX-2 provides a novel target developing more effective NSAIDswith fewer side effects On the basis of results from the structure-activity relationships (SAR) ofselective COX-2 inhibitors. we have designed and synthesized some promising compounds. The discovery of COX-2 provides a novel target developing more effective NSAIDs with fewer side effects On the basis of results from the structure-activity relationships (SAR) of selective COX-2 inhibitors. We have designed and synthesized some promising compounds.