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催化酶治疗活化作用 (ＥＣＴＡ)是为了克服由酶过度表达产生药物耐药性的一种新的前体药物策略 ,该方法中即由过度表达酶将设计的特殊酶底物转变成细胞毒素剂。基于ＥＣＴＡ观念 ,用 β 内酰胺酶作为引擎使在耐药微生物体中产生抗菌剂。已证实由β 内酰胺酶水解ＮＢ2 0 0 1形成
Catalytic enzyme therapy activation (ECTA) is a new prodrug strategy to overcome drug resistance caused by overexpression of enzymes by converting a specific enzyme substrate designed to a cytotoxic agent by over-expressing the enzyme . Based on the ECTA concept, β-lactamase is used as an engine to produce antibacterial agents in resistant microorganisms. It has been confirmed that β-lactamase hydrolyzes NB2 0 0 1 to form