氧哌羟苯唑头孢菌素(Cefoperazone)为一第三代头孢菌素。本文报道国产氧哌羟苯唑头孢菌素正常人体内药代动力学研究结果和给药方案的探讨。 在10名健康志愿者中,分别肌注1g,静脉推注1g,静脉滴注1g和2g本品,给药后不同时间留取血、尿标本并记录尿量,用微生物法测定药物浓度。肌注和静注本品的体内药代动力学过程分别符合一房室开放模型和二房室开放模型。 Cefoperazone is a third-generation cephalosporin. This article reports the domestic oxpaczin cephalosporin normal human pharmacokinetic study results and dosing regimen. In 10 healthy volunteers, intramuscular injection of 1g, intravenous injection of 1g, intravenous infusion of 1g and 2g of this product at different times after administration of blood and urine samples were taken and urine output was recorded, and the drug concentration was determined by the microbiological method. Intramuscular and intravenous The pharmacokinetics of the product in vivo pharmacokinetic agreement with one room open model and two room open model.