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目的探讨血清CEA和Ki-67在结直肠癌的表达及其对肝转移的预测作用。方法采用化学发光法动态检测60例结直肠癌患者术后血清CEA水平,采用免疫组化法检测60例结直肠癌术后标本Ki-67表达。结果在26例肝转移组中2,4例(92.3%)患者出现不同程度CEA升高,在34例非肝转移组中共有9(26.5%)例患者出现CEA升高,差异有统计学意义(P=0.004)。结直肠癌原发灶分化程度不同Ki-67表达也有差异。但是不同T分期和N分期同Ki-67表达没有明显联系。Ki-67阳性表达肝转移率明显高于阴性表达肝转移率,不同表达状态其肝转移发生时间差异有统计学意义(P<0.05)。结论血清CEA水平检测同结直肠癌术后肝转移相关;组织Ki-67表达同结直肠癌肿瘤细胞分化程度和术后肝转移发生相关。
Objective To investigate the expression of serum CEA and Ki-67 in colorectal cancer and its role in predicting liver metastasis. Methods Chemiluminescence was used to detect the serum CEA level in 60 patients with colorectal cancer. The expression of Ki-67 in 60 patients with colorectal cancer was detected by immunohistochemistry. Results In 26 patients with liver metastasis, 2,4 cases (92.3%) had different degrees of CEA. There were 9 (26.5%) patients with non-hepatic metastasis with CEA increased, the difference was statistically significant (P = 0.004). The expression of Ki-67 in different degree of primary colorectal cancer differed. However, there was no obvious relationship between different T stage and N stage with Ki-67 expression. Ki-67 positive expression of liver metastasis was significantly higher than that of negative expression of liver metastasis, the expression of liver metastasis in different time was statistically significant (P <0.05). Conclusion Serum CEA levels are correlated with postoperative liver metastases in colorectal cancer patients. The expression of Ki-67 is correlated with the degree of tumor differentiation and postoperative liver metastasis.