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目的观察替吉奥联合奥沙利铂治疗晚期胃癌的疗效和安全性。方法 30例患者随机分为两组各15例,实验组给予替吉奥胶囊(80mg/m2)/d,分2次口服,d1-14;奥沙利铂130mg/m2,静脉滴注,d1。对照组给予替加氟800mg/m2静脉滴注,d1-5;亚叶酸钙100mg静脉滴注,d1-5;奥沙利铂130mg/m2,静脉滴注,d1。3周为1个周期,化疗2周期后评价疗效。结果两组总有效率无统计学差异(P>0.05),两组主要的毒副反应均为消化道反应、血液学毒性及外周神经毒性。结论替吉奥胶囊联合奥沙利铂治疗进展期胃癌安全、有效。
Objective To observe the efficacy and safety of tizogyl and oxaliplatin in the treatment of advanced gastric cancer. Methods Thirty patients were randomly divided into two groups of 15 patients. The experimental group was treated with TIGO capsules (80mg / m2) / d orally twice daily, d1-14, oxaliplatin 130mg / m2, intravenous drip, d1 . Control group was given tegafur 800mg / m2 intravenous infusion, d1-5; leucovorin 100mg intravenous infusion, d1-5; oxaliplatin 130mg / m2, intravenous infusion, d1.3 weeks for a cycle, After 2 cycles of chemotherapy evaluation of efficacy. Results There was no significant difference in the total effective rate between the two groups (P> 0.05). The main toxicities were digestive tract reaction, hematological toxicity and peripheral neurotoxicity in both groups. Conclusion The treatment of advanced gastric cancer with tigeo capsule and oxaliplatin is safe and effective.