论文部分内容阅读
自50年代将甲苯磺丁脲作为口服降糖药以来,磺脲类降糖药(Su)现已成为非胰岛素依赖型糖尿病(NIDDM)的主要治疗药物。由于NIDDM是老年人最常见的糖尿病,因此Su在老年糖尿病病人应用最多,且还在增加。估计60岁以上糖尿病病人中70％服用Su,因此有必要对其临床药理、作用机制、临床应用特别是老年人用药等问题进行讨论。 一、临床药理 目前尚无有关Su在老年糖尿病的药物动力学方面的专门资料。在使用时应考虑到老年人各器官的功能状态及Su的代谢和排
Sulfonylurea drugs (Su) are now the mainstay of non-insulin-dependent diabetes mellitus (NIDDM) since tolbutamide was used as an oral hypoglycemic agent in the 1950s. Because NIDDM is the most common form of diabetes in the elderly, Su is the most commonly used and is still increasing in elderly diabetic patients. It is estimated that 70% of diabetic patients over the age of 60 take Su, so it is necessary to discuss its clinical pharmacology, mechanism of action, clinical applications, especially the elderly medication. First, the clinical pharmacology There is no relevant information on Su in the pharmacokinetics of elderly diabetes. In the use of the elderly should take into account the functional status of each organ and Su metabolism and row