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纳洛酮 (ｎａｌｏｘｏｎｅ ,ＮＸ)是 196 0年合成的阿片受体拮抗剂 ,为羟二氢吗啡酮的衍生物。 196 1年Ｂｌｕｍｂｅｒｇ报道ＮＸ能拮抗羟二氢吗啡酮所致实验动物的镇痛及呼吸抑制作用。 196 3年Ｆｏｌｄｅｓ在临床观察到了ＮＸ对麻醉镇痛的拮抗作用及麻醉过量中毒的治疗作用 ,
Naloxone (NX) is an opioid receptor antagonist synthesized in 1960 and is a derivative of dihydroxymorphine. 196 1 year Blumberg reported that NX can antagonize the analgesic and respiratory inhibition effects of dihydro-morphine-induced experimental animals. 196 3 years Foldes in the clinical observation of the antagonistic effect of narcotic analgesia NX and anesthesia overdose poisoning treatment,