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目的 :探讨榄香烯乳加 5氟脲嘧啶 (EF方案 )治疗晚期胃癌的疗效。方法 :6 8例晚期胃癌随机分为两组 ,一组采用EF方案 ,另一组采用 5氟脲嘧啶、阿霉素和丝裂霉素 (FAM)作为对照观察。结果 :近期疗效EF组和FAM组分别为 37 5 %和44 4% ,两组无显著差异 (P >0 0 5 ) ,但生活质量改善率分别为 6 8 7%和 5 0 0 % ,EF组明显优于FAM组 (P <0 0 5 ) ,且前者副反应少。结论 :榄香烯乳加 5氟脲嘧啶是治疗晚期胃癌的有效方案 ,特别是改善病人生活质量有明显疗效
Objective: To investigate the efficacy of elemene milk plus 5-fluorouracil (EF regimen) in the treatment of advanced gastric cancer. Methods: Sixty-eight patients with advanced gastric cancer were randomly divided into two groups: one group was treated with EF regimen, and the other group was treated with 5-fluorouracil, doxorubicin, and mitomycin (FAM) as controls. Results: The short-term efficacy of EF group and FAM group were 37.5% and 44.4% respectively. There was no significant difference between the two groups (P > 0 05), but the quality of life improvement rate was 68.7% and 500% respectively. The group was significantly better than the FAM group (P <0 05), and the former had less side effects. Conclusion : Elemene plus 5 fluorouracil is an effective treatment for advanced gastric cancer, especially for improving the quality of life of patients.