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目的观察甲状腺功能减退对妊娠结局的影响。方法选取2014年1月-2016年1月该院60例合并甲状腺功能减退孕产妇为甲状腺功能减退组,同期健康孕产妇60例为健康组,统计两组孕产妇妊娠结局及新生儿情况。结果甲状腺功能减退组孕产妇孕早期、孕中期、孕晚期及产后1 d TSH表达水平均低于健康组(P<0.05)。甲状腺功能减退组孕产妇贫血、胎盘早剥、前置胎盘、流产、早产发生率均高于健康组(P<0.05),且甲状腺功能减退组孕产妇产后出血量多于健康组(P<0.05)。甲状腺功能减退组胎儿窘迫、低体重儿及胎儿生长受限发生率均高于健康组(P<0.05),且甲状腺功能减退组新生儿Apgar评分低于健康组(P<0.05)。结论甲状腺功能减退对孕产妇及新生儿结局可产生负面影响,孕产妇及新生儿并发症均增加,临床应重视。
Objective To observe the effect of hypothyroidism on pregnancy outcome. Methods From January 2014 to January 2016, 60 patients with hypothyroidism in the hospital were hypothyroidism group, and 60 healthy pregnant women in the same period were selected as healthy group. Pregnancy outcome and neonatal status were compared between the two groups. Results The levels of TSH expression in pregnant women with hypothyroidism in early pregnancy, second trimester, third trimester and postnatal day 1 were lower than those in healthy group (P <0.05). Hypothyroidism group maternal anemia, placental abruption, placenta previa, abortion, the incidence of preterm birth were higher than the healthy group (P <0.05), and hypothyroidism group of postpartum hemorrhage more than healthy group (P <0.05 ). The incidence of fetal distress, low birth weight infants and fetal growth restriction in hypothyroidism group were higher than that in healthy group (P <0.05), and the neonatal Apgar score in hypothyroidism group was lower than that in healthy group (P <0.05). Conclusions Hypothyroidism can have a negative impact on maternal and neonatal outcomes, maternal and neonatal complications have increased, the clinical should pay attention.