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诱变剂直接作用于染色体或染色单体以及纺锤体时,可诱发染色体断片和迟滞染色体,它们在细胞分裂过程中形成微核.诱变剂的种类和作用各异,所以识别由断片或迟滞染色体形成的两种类型的微核具有重要意义.显然,由染色体断片形成的微核比由整条染色体形成的微核小,这一点Yamamoto等人于1980年在小鼠骨髓多染性红细胞的微核研究中给予证实.然而,人类染色体的长短相差悬殊,有时染色体断片和整条染色体大小可能接近,且都能形成微核.本研究的目的是探讨Yamamoto等人的发现能否适用于人淋巴细胞微核.
Mutagens act directly on chromosomes or chromatids as well as spindles and can induce chromosomal fragmentation and hysteresis chromosomes, which form micronuclei during cell division. Mutagens vary in kind and function, so identification by fragments or hysteresis Two types of micronuclei formed by chromosomes are of great importance: Obviously, the micronuclei formed by the chromosome fragments are smaller than the micronuclei formed by the entire chromosomes, and Yamamoto et al., 1980 in mouse bone marrow polychromatic erythrocytes However, human chromosomes vary greatly in length, sometimes chromosome fragments and the entire chromosome size may be close, and can form micronuclei. The purpose of this study is to investigate whether Yamamoto et al.’s findings are applicable to humans Lymphocyte micronuclei.