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目的:探讨重度子痫前期患者肝肾功能损害情况。方法:以2008年1~12月住院的119例重度子痫前期患者为重度子痫前期(S-PE)组,以同期正常单胎晚期妊娠孕妇116例为对照组,采集孕妇清晨空腹静脉血,测定血浆ALT、AST、TP、ALB、Cre及Bun。结果:S-PE组孕妇的ALT值(33.97±10.53)U/L高于对照组的(14.06±13.89)U/L,差异有统计学意义(P<0.05);S-PE组孕妇的AST值(44.97±87.38)U/L高于对照组的(20.92±10.18)U/L,差异有统计学意义(P<0.01);S-PE组孕妇的TP(57.55±6.37)g/L明显低于对照组的(66.24±5.05)g/L,差异有统计学意义(P<0.01);S-PE组孕妇的ABL值(31.59±4.27)g/L低于对照组的(38.56±2.89)g/L,差异有统计学意义(P<0.01);S-PE组Cre值(79.72±24.01)μmol/L高于对照组(58.38±6.58)μmol/L,差异有统计学意义(P<0.01);S-PE组Bun值为(6.22±3.20)μmol/L,高于对照组的(3.53±0.90)μmol/L,差异有统计学意义(P<0.01);S-PE组孕妇24 h尿蛋白定量为(5.69±3.26)g。结论:重度子痫前期患者由于全身小血管痉挛,导致肝肾等重要脏器功能损害,甚至产生多脏器功能衰竭,故应早诊断早治疗。
Objective: To investigate the liver and kidney dysfunction in patients with severe preeclampsia. Methods: One hundred and ninety-nine patients with severe preeclampsia admitted to hospital from January to December in 2008 were selected as severe preeclampsia (S-PE) group. 116 pregnant women with normal singleton pregnancy in the same period were taken as control group. Early fasting venous blood Plasma ALT, AST, TP, ALB, Cre and Bun were measured. Results: The ALT (33.97 ± 10.53) U / L of pregnant women in S-PE group was significantly higher than that of control group (14.06 ± 13.89) U / L, the difference was statistically significant (P <0.05) (44.97 ± 87.38) U / L was higher than that of the control group (20.92 ± 10.18) U / L, the difference was statistically significant (P <0.01). The TP (57.55 ± 6.37) g / L of pregnant women in S-PE group was significantly (66.24 ± 5.05) g / L in the control group (P <0.01). The ABL of the pregnant women in the S-PE group (31.59 ± 4.27) g / L was lower than that of the control group (38.56 ± 2.89 (P <0.01). The Cre value in S-PE group (79.72 ± 24.01) μmol / L was significantly higher than that in control group (58.38 ± 6.58) μmol / L, with significant difference (P <0.01). The Bun value in S-PE group was (6.22 ± 3.20) μmol / L, which was significantly higher than that in control group (3.53 ± 0.90) μmol / L 24 h urinary protein was (5.69 ± 3.26) g. Conclusion: Severe preeclampsia patients with systemic small vasospasm, leading to liver and kidney damage and other important organ dysfunction, and even multiple organ failure, it should be early diagnosis and treatment.