Nanozymes,nanomaterials with enzyme-like activity,have been considered as promising alternatives of natural enzymes.Molecular logic gates,which can simulate the function of the basic unit of an elec-tronic computer,perform Boolean logic operation in response to chemical,biological,or optical signals.Recently,the combination of nanozymes and logic gates enabled bioinformation processing in a logi-cally controllable way.In the review,recent progress in the construction of nanozyme-based logic gates integrated with their utility in sensing is introduced.Furthermore,the issues and challenges in the construction processes are discussed.It is expected the review will facilitate a comprehensive under-standing of nanozyme-based logic systems.