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目的研究奥沙利铂对人MGC-803胃癌细胞株中XIAP表达及凋亡的影响,探讨其诱导凋亡的作用机制。方法应用流式细胞仪检测XIAP表达及凋亡的情况。结果奥沙利铂对XIAP表达有明显的抑制作用(P<0.05),凋亡率明显高于对照组(P<0.01)。结论奥沙利铂具有抑制MGC-803胃癌细胞株中XIAP表达,诱导胃癌细胞凋亡作用,其机制与抗凋亡相关基因表达减弱有关。
Objective To study the effect of oxaliplatin on XIAP expression and apoptosis in human gastric cancer cell line MGC-803 and to explore its mechanism of apoptosis induction. Methods Flow cytometry was used to detect the expression of XIAP and apoptosis. Results Oxaliplatin significantly inhibited the expression of XIAP (P <0.05), and the apoptosis rate was significantly higher than that of the control group (P <0.01). Conclusion Oxaliplatin inhibits the expression of XIAP in gastric cancer cell line MGC-803 and induces the apoptosis of gastric cancer cells. The mechanism is related to the weakened expression of anti-apoptosis related genes.