在肠胃外用药品中,最常见的热原为革兰氏阴性菌细胞膜外表面的细菌内毒素。这种脂多糖是产生多种生物活性的原因,最熟知的生物活性是,如果细菌内毒素经肠胃外途径注射入人或动物体内,就可以引起发热。早在1940年,美国药典委员会开始制订法定热原检查法时,就选用致热性作为肠胃外用溶液有无热原的指标。食品药品管理局(FDA)、国家卫生研究所(NIH)和14家药 In parenterals, the most common pyrogen is bacterial endotoxin on the outer surface of Gram-negative bacterial membranes. This lipopolysaccharide is responsible for a variety of biological activities. The best known biological activity is that if bacterial endotoxin is injected into a human or animal by the parenteral route, it can cause fever. As early as 1940, the United States Pharmacopoeia Commission began to develop the legal pyrogen test, the selection of pyrogenic as a parenteral solution with or without pyrogen index. Food and Drug Administration (FDA), National Institutes of Health (NIH) and 14 drugs