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目的:探讨丙戊酸钠联合左乙拉西坦对小儿难治性癫痫的治疗效果。方法:抽取2018年1月至2020年1月于洛阳市第一人民医院接受治疗的108例难治性癫痫患儿为研究对象，采用随机数字表将其分为A组(35例)、B组(34例)与C组(39例)。所有患儿均给予以奥卡西平为主的基础药物治疗，A组在基础疗法上单纯加用丙戊酸钠治疗，B组单纯加用左乙拉西坦治疗，C组同时加用丙戊酸钠与左乙拉西坦治疗。分析治疗6个月后两组患儿癫痫发作频次减少率、脑电图异常节律转阴率及治疗6个月内药物不良反应发生率，比较治疗前及治疗6个月后两组患儿脑电图参数变化。结果:治疗6个月后，C组癫痫发作频次减少率及脑电图异常节律转阴率高于A、B组(n P<0.05)；三组患儿患侧脑区α1、α2、θ频段绝对功率较治疗前下降(n P<0.05)，C组α1、α2、θ频段绝对功率低于A、B组(n P0.05)。n 结论:丙戊酸钠联合左乙拉西坦治疗难治性小儿癫痫效果较好，可有效改善患儿脑电图，且安全性良好。“,”Objective:To explore the application effects of sodium valproate combined with levetiracetam on children with intractable epilepsy.Methods:A total of 108 children with intractable epilepsy in Luoyang First People’s Hospital from January 2018 to January 2020 were selected as the research subjects, and they were divided into group A (n n=35), group B (n n=34) and group C (n n=39) by simplified random grouping of random number table. All children were treated with oxcarbazepine-based basic drugs, and on the basis of basic therapy, group A was treated with sodium valproate alone, group B was treated with levetiracetam alone, and group C was treated with sodium valproate and levetiracetam. The reduction rate of epileptic seizure frequency and negative conversion rate of abnormal electroencephalogram rhythms after 6 months of treatment and incidence rates of adverse drug reactions within 6 months were compared among the groups. Changes in electroencephalogram parameters were compared among the groups before treatment and after 6 months of treatment.n Results:After 6 months of treatment, the reduction rate of epileptic seizure frequency and negative conversion rate of abnormal electroencephalogram rhythms in group C were higher than those in group B or group A (n P<0.05). The absolute powers of the α1, α2 and θ frequency bands in the affected brain side in the three groups were decreased compared with those before treatment (n P<0.05), and the absolute powers of α1, α2 and θ frequency bands in group C were significantly lower than those in group A and group B (n P0.05).n Conclusions:Sodium valproate combined with levetiracetam has prominent effects in the treatment of children with intractable epilepsy. It can effectively improve electroencephalogram, and the combination of medication has good safety.