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患儿(13岁)于1972年10月入院治疗。其时白细胞数2.5×10~/1,32%为原淋细胞。骨髓呈均一性细胞群重度浸润,稍大于淋巴细胞,含颗粒性染色质,有1～3个不明显核仁以及一条澄明蓝色无颗粒的狭缘胞浆。未作细胞化学分析及细胞膜标志研究。经用长春新碱、柔红霉索及强的松获得完全缓解。巩固治疗包括持续使用6-巯基嘌呤以及定期的长春新碱和强的松再诱导治疗。1975年5月中枢神经系统复发时,采用过放疗及鞘内氨甲喋呤治疗。1977年7月停止巩固治疗。
The child (13 years old) was admitted to hospital in October 1972. At that time, the number of white blood cells was 2.5×10~/1, 32% of the original lymphocytes. The bone marrow was heavily infiltrated with a homogenous population of cells, slightly larger than lymphocytes, containing granular chromatin, 1 to 3 invisible nucleoli, and a clear blue, particulate-free, thin margin cytoplasm. No cytochemical analysis and cell membrane markers were studied. Complete remission was achieved with vincristine, daunorubicin, and prednisone. Consolidation therapy includes the continued use of 6-mercaptopurine and regular vincristine and prednisolone induction therapy. When the central nervous system relapsed in May 1975, over radiotherapy and intrathecal methotrexate treatment were used. In July 1977, the consolidation of treatment was stopped.