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环磷酰胺是一种很强的致大鼠胚胎神经管畸形和骨骼发育异常的物质，利用叶酸和维生素Ｃ拮抗其胚胎毒和畸胎毒的作用。结果环磷酰胺＋维生素组胎鼠脑膨出发生率为１０．６％，顶骨骨化障碍发生率为１１．３％，明显低于环磷酰胺组的９８．３％和１００％，（Ｐ＜０．００１）；胎鼠平均体重为３．８ｇ，明显高于环磷酰胺组的２．１ｇ，Ｐ＜０．００１。光镜观察神经管，可见环磷酰胺＋维生素组神经管上皮的损伤轻于环磷酰胺组，其细胞分裂增生则明显比环磷酰胺组活跃。表明叶酸、维生素Ｃ有明显促进胚胎发育和拮抗环磷酰胺的致畸作用。
Cyclophosphamide is a potent substance that induces neural tube defects and skeletal dysgenesis in rat embryos. It uses folic acid and vitamin C to antagonize their embryonic and teratogenic effects. Results The incidence of encephalocele was 10.6% in fetal cyclophosphamide + vitamin group and 11.3% in maxilla, which was significantly lower than 98.3% and 100% in cyclophosphamide group (P <0.001). The average body weight of fetus was 3.8g, which was significantly higher than that of cyclophosphamide group (2.1g, P <0.001). Light microscope observation of neural tube, visible cyclophosphamide + vitamin group, neural tube epithelial injury was less than cyclophosphamide group, the cell division proliferation was significantly more active than cyclophosphamide group. That folic acid, vitamin C can significantly promote embryonic development and antagonize the teratogenic effects of cyclophosphamide.