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目的比较FND(福达拉滨+米托蒽醌+地塞米松)与CHOP持续滴注方案治疗惰性淋巴瘤的临床疗效及毒副作用。方法 104例初、复治惰性淋巴瘤患者随机分为3组。A组:FND方案初治组;B组:FND方案复治组;C组:CHOP方案持续滴注初治组。AB组均选用FND方案:氟达拉滨25mg/m2,iv d1～3;MXT 10mg/m2,iv d1;DXM 20 mg/d,iv d1～5。C组选用CHOP持续滴注方案:CTX 750 mg/m2,iv d1;ADM 50mg/m2+VCR 1.4mg/m2+NS 200mL微电脑持续泵入120h;PDN 100mg/d,po d1～5。结果 A组的总CR率55.6%,B组29.0%,C组27.0%。A组CR率高于B组(P<0.025),亦高于C组(P<0.025),具有显著性统计学差异。A组总有效率80.5%,B组58.1%,C组62.2%。A组高于B组(P<0.05),具有显著性统计学差异。亦高于C组,但差异不显著(P>0.05)。结论采用FND方案,惰性淋巴瘤初治患者的疗效,优于复治患者及CHOP方案持续滴注初治患者。
Objective To compare the clinical efficacy and side effects of FND (Fadalafil + mitoxantrone + dexamethasone) and CHOP continuous infusion regimen in the treatment of indolent lymphoma. Methods A total of 104 patients with initial retreatment of idiopathic lymphoma were randomly divided into 3 groups. Group A: FND regimen naive group; Group B: FND regimen; Group C: CHOP regimen. The FND regimens were selected in the AB group: fludarabine 25 mg / m2, iv d1-3; MXT 10 mg / m2, iv d1; DXM 20 mg / d, iv d1-5. The patients in group C were given continuous infusion of CHOP: CTX 750 mg / m2, iv d1; ADM 50 mg / m2 + VCR 1.4 mg / m2 + NS 200 mL microcomputer for 120 h; PDN 100 mg / d, po d1-5. Results The total CR rate in group A was 55.6%, in group B 29.0% and in group C 27.0%. The CR rate in group A was higher than that in group B (P <0.025) and also higher than that in group C (P <0.025), with significant difference. The total effective rate in group A was 80.5%, in group B 58.1% and in group C 62.2%. A group than in group B (P <0.05), with significant statistical differences. Also higher than C group, but the difference was not significant (P> 0.05). Conclusion The efficacy of the FND regimen in patients with newly diagnosed idiopathic lymphoma is better than that of retreatment patients and CHOP regimen.