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目的探索超声检测宫颈长度(CL)及宫颈分泌物检测胎儿纤维连接蛋白(fFN)对早产预测的临床价值。方法 80例具有早产高危因素的孕妇为本次研究的对象,全部孕妇均于24~35周接受经阴道超声检查CL,采集宫颈分泌物检测fFN,追踪妊娠结局。结果 CL>30 mm组早产率13.04%,15~30 mm组早产率为34.78%,<15 mm组早产率为72.73%,三组早产情况比较,差异有统计学意义(P<0.05);在同一宫颈长度组中,fFN阳性组孕妇早产率明显高于阴性组(P<0.05);CL+fFN检测对早产的阳性预测值明显高于CL检测(P<0.05)。结论 CL和fFN检测的联合应用有助于临床医师对早产风险进行评估预测,从而根据风险的大小采取妊娠期的早期干预措施,保障母婴安全。
Objective To explore the clinical value of detecting the cervical length by ultrasound (CL) and the detection of fetal fibronectin (fFN) by cervical secretions in the prediction of preterm birth. Methods 80 pregnant women with risk factors for preterm birth were the subjects of this study. All pregnant women underwent transvaginal ultrasonography CL at 24-35 weeks. Cervical secretions were collected to detect fFN and the pregnancy outcome was tracked. Results The preterm birth rate was 13.04% in CL> 30 mm group, 34.78% in 15-30 mm group, and 72.73% in <15 mm group. There was significant difference in the preterm birth among the three groups (P <0.05) In the same cervical length group, the preterm birth rate of fFN positive group was significantly higher than that of negative group (P <0.05). The positive predictive value of CL + fFN for preterm birth was significantly higher than that of CL (P <0.05). Conclusions The combined application of CL and fFN test can help clinicians to assess and predict the risk of preterm birth and thus take early gestational pregnancy intervention according to the risk to ensure the safety of mother and baby.