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目的从血清学的检测结果探讨新疆地区获得性免疫缺陷综合征的流行特征和趋势。方法2001至2004年本院对外科手术之前常规检测和临床各科疑诊送检血清36021份,应用ELISA和金标法筛检后送区疾控中心艾滋病监测中心WB法确认,RTPCR方法测HIVRNA的载量,流式细胞仪检测CD细胞。结果抗HIV阳性259例,占0.714%。女性占38%(97/259)有增高倾向并出现宫内感染3例。16～35岁占80%,维族占85.6%,静脉吸毒和无业人群各占94%和67.7%。北疆占83.3%,南疆占8.69%。病毒核酸检出率达50%,其中104～105cop/ml占76%(19/25),CD4、CD8CD4/CD8均有异常,其中CD4/CD8比值降低达96%,CD4降低56%,CD8升高60%,住院病人逐渐增多。因此感染死亡者占80%,自发骨折占外科16.7%。结论血清学抗HIV、HIVRNA,CD细胞检测证实新疆发病晚,进展快,女性感染率上升存在宫内感染,已进入发病和死亡的增长期,抗病毒治疗势在必行。
Objective To investigate the prevalence and trend of acquired immunodeficiency syndrome in Xinjiang from serological test results. Methods From 2001 to 2004, the hospital routinely detected before surgery and clinical departments of suspected seizure of 36,021 serums, using ELISA and gold standard screening evacuation zone CDC AIDS monitoring center confirmed by WB method, RTPCR method to detect HIV RNA The flow cytometry was used to detect CD cells. Results The anti-HIV positive 259 cases, accounting for 0.714%. Women accounted for 38% (97/259) tended to increase and intrauterine infection in 3 cases. 16 to 35 years old accounted for 80%, Uygur accounted for 85.6%, intravenous drug users and unemployed people each accounted for 94% and 67.7%. North Xinjiang accounted for 83.3%, South Xinjiang accounted for 8.69%. The detection rate of virus nucleic acid was 50%, among which 104 ~ 105cop / ml accounted for 76% (19/25), CD4, CD8CD4 / CD8 were abnormal, CD4 / CD8 ratio decreased 96%, CD4 decreased 56%, CD8 60% higher, inpatient gradually increased. So 80% died of infection, spontaneous fracture accounted for 16.7% of surgery. Conclusions The results of serological anti-HIV, HIV-RNA and CD-cell confirmed late onset and rapid progression of infection in Xinjiang. Intrauterine infection was found in women with increased infection rate and had entered an increasing period of morbidity and mortality. Antiviral therapy was imperative.