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克隆病(crohn disease,CD)是一组病因未明的胃肠道慢性炎性肉芽肿疾病。病变多见于末端回肠及升结肠,但从口腔至肛门各段消化道均可受累。病情轻重不一,病程迁延,容易复发。治疗CD的药物主要有:①抗生素;②糖皮质激素;③免疫抑制剂。尽管治疗CD的药物很多,但目前没有一种药物是理想的或被广泛接受的。由于国外,尤其是欧、美地区CD发病率相对较高,故国外对CD药物治疗的研究较多,并取得了一些进展。
Crohn’s disease (CD) is a group of chronic inflammatory granulomatous diseases of the gastrointestinal tract of unknown etiology. Lesions more common in the terminal ileum and ascending colon, but from the mouth to the anus of the digestive tract may be involved. Different severity, duration of the disease, easy to relapse. The treatment of CD drugs are: ① antibiotics; ② glucocorticoid; ③ immunosuppressive agents. Although there are many drugs that treat CDs, no one is ideal or widely accepted. Due to the relatively high incidence of CD in foreign countries, especially in Europe and the United States, CD drug therapy abroad has been more studied and some progress has been made.