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目的 :观察葛根素葡萄糖注射液对犬急性心肌缺血的影响。方法 :结扎犬冠状动脉左前降支造成急性心肌缺血模型 ,葛根素葡萄糖注射液 83mg·kg-1连续 4h静脉滴注 ,观察心外膜电图、酶及心肌病理染色 (N BT)的变化。结果 :葛根素葡萄糖注射液可明显改善心电图指标 ,限制心肌梗死范围 ,降低血清肌酸激酶 (CK) ,肌酸激酶同工酶 (CK MB) ,AST ,乳酸脱氢酶 (LDH)水平。结论 :葛根素葡萄糖注射液对犬实验性心肌缺血有较好的治疗作用
Objective: To observe the effect of puerarin glucose injection on acute myocardial ischemia in dogs. Methods: Acute myocardial ischemia was induced by ligation of canine left anterior descending coronary artery in dogs. Puerarin and glucose injection 83mg · kg-1 was given intravenously for 4h continuously to observe the changes of epicardiogram, enzyme and cardiomyopathy (N BT) . Results: Puerarin and glucose injection can significantly improve the ECG indicators, limit the scope of myocardial infarction, reduce serum creatine kinase (CK), creatine kinase MB (CK MB), AST, lactate dehydrogenase (LDH) levels. Conclusion: Puerarin and glucose injection have a good therapeutic effect on experimental myocardial ischemia in dogs