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Background::Postural tachycardia syndrome (POTS) is a common childhood disease that seriously affects the patient’s physical and mental health. This study aimed to investigate whether pre-treatment baseline left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) values were associated with symptom improvement after metoprolol therapy for children and adolescents with POTS.Methods::This retrospective study evaluated 51 children and adolescents with POTS who received metoprolol therapy at the Peking University First Hospital between November 2010 and July 2019. All patients had completed a standing test or basic head-up tilt test and cardiac echocardiography before treatment. Treatment response was evaluated 3 months after starting metoprolol therapy. The pre-treatment baseline LVEF and LVFS values were evaluated for correlations with decreases in the symptom score after treatment (ΔSS). Multivariable analysis was performed using factors with an P value of 0.050). However, responders had significantly higher baseline LVEF (71.09% ± 4.44% n vs. 67.17% ± 4.88%, n t = -2.789, n P = 0.008) and LVFS values (40.00 [38.00, 42.00]% n vs. 36.79% ± 4.11%, n Z = -2.542, n P = 0.010) than the non-responders. The baseline LVEF and LVFS were positively correlated with ΔSS ( n r = 0.378, n P = 0.006; n r = 0.363, n P = 0.009), respectively. Logistic regression analysis revealed that LVEF was independently associated with the response to metoprolol therapy in children and adolescents with POTS (odds ratio: 1.201, 95% confidence interval: 1.039-1.387, n P = 0.013).n Conclusions::Pre-treatment baseline LVEF was associated with symptom improvement after metoprolol treatment for children and adolescents with POTS.“,”Background::Postural tachycardia syndrome (POTS) is a common childhood disease that seriously affects the patient’s physical and mental health. This study aimed to investigate whether pre-treatment baseline left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) values were associated with symptom improvement after metoprolol therapy for children and adolescents with POTS.Methods::This retrospective study evaluated 51 children and adolescents with POTS who received metoprolol therapy at the Peking University First Hospital between November 2010 and July 2019. All patients had completed a standing test or basic head-up tilt test and cardiac echocardiography before treatment. Treatment response was evaluated 3 months after starting metoprolol therapy. The pre-treatment baseline LVEF and LVFS values were evaluated for correlations with decreases in the symptom score after treatment (ΔSS). Multivariable analysis was performed using factors with an P value of 0.050). However, responders had significantly higher baseline LVEF (71.09% ± 4.44% n vs. 67.17% ± 4.88%, n t = -2.789, n P = 0.008) and LVFS values (40.00 [38.00, 42.00]% n vs. 36.79% ± 4.11%, n Z = -2.542, n P = 0.010) than the non-responders. The baseline LVEF and LVFS were positively correlated with ΔSS ( n r = 0.378, n P = 0.006; n r = 0.363, n P = 0.009), respectively. Logistic regression analysis revealed that LVEF was independently associated with the response to metoprolol therapy in children and adolescents with POTS (odds ratio: 1.201, 95% confidence interval: 1.039-1.387, n P = 0.013).n Conclusions::Pre-treatment baseline LVEF was associated with symptom improvement after metoprolol treatment for children and adolescents with POTS.