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为探讨人乳头状瘤病毒（HPV）感染与鼻内翻性乳头状瘤（IP）发病及其恶变的关系，研究选取经组织病理确诊为IP（36例）和IP癌变（16例）的石蜡包埋标本，采用多聚酶链反应（PCR）方法对标本进行HPV相关DNA序列扩增。结果显示；36例IP组织有21例（58．3％）为HPV阳性；16例IP癌变组织中有11例（68．8％）阳性。经统计学处理，二者间无显著性差异（P＞0．05）。提示HPV感染在IP的发生过程中发挥一定的作用，而IP癌变的过程还需要HPV感染以外的致癌因素参与。
To investigate the relationship between human papillomavirus (HPV) infection and the pathogenesis and the malignant transformation of nasal inverted papilloma (IP), we selected paraffin (36 cases) and IP carcinogenesis (16 cases) diagnosed by histopathology Embedding specimens, using polymerase chain reaction (PCR) method on the specimens for HPV-related DNA sequence amplification. The results showed that in 36 cases of IP tissue, 21 cases (58.3%) were HPV positive; 11 cases (68.8%) were positive in 16 cases of IP cancerous tissue. Statistically, no significant difference between the two (P> 0.05). Tip HPV infection in the occurrence of IP play a role in the process, and IP carcinogenesis process also requires HPV infection in addition to the carcinogenic factors involved.