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目的:研究甲基强的松龙联合神经节苷脂治疗急性脊髓炎患者的临床疗效和对神经功能影响。方法:选取2010年5月至2015年2月收治的108例急性脊髓炎患者,采用随机数字表法将患者分为对照组和观察组,各54例。对患者均进行临床常规治疗,在此基础上对照组静脉给予甲基强的松龙治疗,观察组采用甲基强的松龙联合神经节苷脂治疗,比较两组临床治疗效果及各项临床指标恢复情况,同时比较治疗前后两组感知功能及运功功能评分。结果:观察组治疗总有效率为94.44%,明显高于对照组的81.48%(χ2=4.96,P=0.02);在独立行走、括约肌功能恢复及肢体肌肉恢复二级以上时间上,观察组均明显低于对照组(P<0.01);观察组患者的感知功能和运动功能评分均明显高于对照组(P<0.01)。结论:甲基强的松龙联合神经节苷脂在急性脊髓炎患者治疗中的临床效果显著,可同时促进机体各肌肉组织恢复正常,有效改善患者的运动及感知功能,明显提升患者的预后质量,值得在临床中推广。
Objective: To study the clinical effect and neurological function of methylprednisolone combined with ganglioside in the treatment of acute myelitis. Methods: One hundred and eighty patients with acute myelitis admitted from May 2010 to February 2015 were selected and divided into control group and observation group by random number table. On the basis of the control group intravenous methylprednisolone treatment, the observation group was treated with methylprednisolone and ganglioside, the clinical efficacy of the two groups were compared and the clinical Index recovery, at the same time compare the two groups before and after the treatment of cognitive function and functional motor function score. Results: The total effective rate of the observation group was 94.44%, which was significantly higher than that of the control group (χ2 = 4.96, P = 0.02). In the independent walking, sphincter recovery and limb muscle recovery more than two times, the observation group (P <0.01). The scores of sensory function and motor function in the observation group were significantly higher than those in the control group (P <0.01). CONCLUSION: Methylprednisolone combined with ganglioside has a significant clinical effect in the treatment of patients with acute myelitis, which can promote the normalization of muscle tissues of the body and effectively improve the motor and sensory function of the patients and significantly improve the prognosis quality , It is worth to promote in the clinic.