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目的探讨血清肺炎支原体抗体IgM和IgG在沈阳地区呼吸道感染患儿的阳性检出率及其感染与年龄、性别和季节的关系。方法采用被动凝集法和金标免疫斑点法检测血清中肺炎支原体抗体,回顾分析2010年1-12月15岁以下7 023例呼吸道感染患儿肺炎支原体抗体IgM和IgG的检测结果。结果肺炎支原体抗体总阳性检出率为36.6%(2 569/7 023),IgM和IgG的阳性率分别为36.1(2 536/7 023)%和8.5%(597/7 023);不同性别间IgM差异有统计学意义(P<0.01);不同季节IgM阳性检出率差异有统计学意义(P<0.01),以秋季为最高,IgG以冬季为最高;血清IgM和IgG的阳性检出率各年龄组间差异均有统计学意义(P<0.01)。结论沈阳地区呼吸道感染患儿肺炎支原体感染占1/3以上,秋季多发,随着年龄增加,感染率逐渐增加,发病率女性高于男性。
Objective To investigate the positive detection rate of serum mycoplasma pneumoniae antibody IgM and IgG in children with respiratory tract infection in Shenyang and its relationship with age, sex and season. Methods The serum samples of Mycoplasma pneumoniae were detected by passive agglutination and gold standard immunofluorescence. The results of IgM and IgG in Mycoplasma pneumoniae from 7 023 children aged below 15 years old aged from January to December 2010 were retrospectively analyzed. Results The positive rate of mycoplasma pneumoniae antibody was 36.6% (2 569/7 023), the positive rates of IgM and IgG were 36.1 (22 536/7 023)% and 8.5% (597/7 023) respectively. (P <0.01). The positive rate of IgM in different seasons was statistically significant (P <0.01), the highest in autumn, the highest in IgG in winter, and the positive rate of IgM and IgG in serum The differences among all age groups were statistically significant (P <0.01). Conclusions Mycoplasma pneumoniae infection in children with respiratory tract infection in Shenyang accounts for more than one third of the cases. In autumn, multiple infections occur. As the age increases, the infection rate gradually increases, and the incidence is higher in women than in men.