本文就肠化生和间变的病理学特点,与胃溃疡和胃癌的关系以及其亚型与胃癌风险作一综述.本文还将就两大类型胃癌表型和基因型,间变和肠化生与肠型胃癌的关系及肠型胃癌产生的分子生物学模型等作一讨论. This article reviews the pathological features of intestinal metaplasia and metamorphosis, the relationship with gastric ulcer and gastric cancer, and the risk of subtypes and gastric cancer. This article will also discuss the phenotype and genotype of two major types of gastric cancer, metamorphosis and intestinal metaplasia. The relationship between birth and intestinal type gastric cancer and the molecular biology model of intestinal type gastric cancer were discussed.