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酸甘止痒合剂小鼠24小时内口服176g/kg(相当于临床用量的328倍),观察7天,无不良反应,无死亡.因已达最大药液浓度和最大胃纳量,故未测出LD_(50).大鼠口服33g/kg,连续给药60天(每日用量相当于临床用量72倍),对大鼠肝肾功能(SGPT及BUN值)和血象均无明显影响.各给药组用药前后体重比较,均明显增加,且与对照组比较其增重的差别无显著性,说明该制剂对大鼠的生长发育无抑制作用.解剖肉眼观察及镜检,大鼠心、肝、肾组织形态未见特殊改变.停药两周后重复上述各项检查无异常发现.该制剂对组胺所致的豚鼠局部皮肤反应和组胺所致的家兔肠平滑肌收缩反应均有明显抑制作用.对小鼠腹腔巨噬细胞的吞噬功能和胸腺、脾脏的增长亦有明显抑制作用.
The mice with sour Ganzhizhiting were taken orally at 176 g/kg (equivalent to 328 times the clinical dosage) within 24 hours. After 7 days of observation, there were no adverse reactions and no deaths. Since the maximum drug concentration and maximum appetite level had been reached, it was not LD_(50) was measured. Rats were orally administered with 33 g/kg for 60 consecutive days (the daily dose was equivalent to 72 times the clinical dosage), and had no significant effect on liver and kidney function (SGPT and BUN values) and hemogram of rats. The body weights before and after administration in all groups were significantly increased, and there was no significant difference in weight gain compared with the control group, indicating that the preparation had no inhibitory effect on the growth and development of rats. Anatomical observation and microscopy, rat heart There was no special change in the morphology of the liver or kidneys. Repeated examinations were repeated 2 weeks after discontinuation of the drug. No abnormalities were found. The formulation’s response to histamine-induced local guinea pig skin reactions and histamine-induced rabbit intestinal smooth muscle contraction It has obvious inhibitory effect. It also inhibits the phagocytic function of peritoneal macrophages in mice and the growth of thymus and spleen.