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目的:探讨单独应用低剂量维生素A(Vitmin A)或多种营养素联合应用对新生儿肺炎的辅助治疗效果。方法:选取新生儿肺炎患者128例,随机分为3组:维生素A组口服低剂量维生素A;多种营养素组口服维生素A、维生素E、锌、硒的复合物;对照组口服生理盐水。观察患儿的临床症状和体征变化情况,并于治疗前和治疗7天后采集患儿血液,采用ELISA方法检测视黄醇结合蛋白的含量变化,采用免疫比浊法检测Ig M的含量变化,采用分光光度法检测丙二醛、谷胱甘肽过氧化物酶、超氧化物歧化酶的含量变化。结果:维生素A组和多种营养素组患儿的临床症状持续时间明显短于对照组(P<0.05);维生素A组和多种营养素组患儿治疗前后视黄醇结合蛋白的含量无明显变化(P>0.05),而对照组患儿的视黄醇结合蛋白含量治疗后要明显高于治疗前(P<0.05);维生素A组和多种营养素组患儿血清中Ig M、丙二醛、超氧化物歧化酶的含量,治疗后明显低于治疗前(P<0.05);维生素A组和多种营养素组患儿血清中谷胱甘肽过氧化物酶的含量治疗后明显高于治疗前(P<0.05),而对照组治疗前后无明显变化(P>0.05)。结论:维生素A和多种营养素对新生儿肺炎有明显的辅助治疗作用,能缩短患儿的临床症状持续时间,增强患儿的抗氧化能力。
Objective: To explore the adjuvant therapy of neonatal pneumonia with Vitmin A alone or in combination with multiple nutrients. Methods: A total of 128 neonates with pneumonia were selected and randomly divided into three groups: Vitamin A group orally with low dose of vitamin A; multiple nutrient groups oral vitamin A, vitamin E, zinc, selenium complex; The changes of clinical symptoms and signs of children were observed. Blood samples were collected before treatment and 7 days after treatment. The content of retinol binding protein (BSA) was detected by ELISA. The content of IgM was detected by immunoturbidimetry. Spectrophotometric determination of malondialdehyde, glutathione peroxidase, superoxide dismutase content changes. Results: The duration of clinical symptoms in children with vitamin A group and multiple nutrient groups was significantly shorter than that in control group (P <0.05). There was no significant difference in the levels of retinol binding protein between children with vitamin A group and multiple nutrient groups before and after treatment (P> 0.05). However, the content of retinol binding protein in control group was significantly higher than that before treatment (P <0.05). Serum IgM, malondialdehyde , And the content of superoxide dismutase (SOD) after treatment were significantly lower than those before treatment (P <0.05). The levels of serum glutathione peroxidase in children with vitamin A group and multiple nutrient groups were significantly higher than those before treatment (P <0.05), while there was no significant difference in the control group before and after treatment (P> 0.05). Conclusion: Vitamin A and multiple nutrients have obvious adjuvant therapeutic effects on neonatal pneumonia, which can shorten the duration of clinical symptoms and enhance the anti-oxidation ability of children.