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目的探讨二甲双胍对多囊卵巢综合征(PCOS)患者内分泌及代谢的影响,并评估二甲双胍在PCOS患者治疗中的作用。方法选择PCOS患者36例,予二甲双胍治疗12周(治疗前为A组,治疗后为B组),同期选择月经周期规律的正常妇女26例为对照组(C组),测定各组体重指数(BM I)、性激素、血脂、空腹血糖、空腹胰岛素(FINS),计算胰岛素敏感指数(ISI)。结果①与C组相比,A组BM、I甘油三酯(TG)、低密度脂蛋白-胆固醇(LDL-C)、FINS、黄体生成素(LH)、LH卵/泡刺激素(FSH)、睾酮(T)升高(P<0.05);ISI降低(P<0.01);②与A组相比,B组BM、ITG、LDL-C、FINS、LH、LH/FSH、T降低(P<0.05);ISI升高(P<0.01)。结论二甲双胍能纠正PCOS患者的内分泌及代谢异常,是治疗PCOS的重要手段。
Objective To investigate the effect of metformin on endocrine and metabolism in patients with PCOS and evaluate the role of metformin in the treatment of patients with PCOS. Methods 36 patients with PCOS were selected and treated with metformin for 12 weeks (group A before treatment and group B after treatment). 26 women with normal menstrual cycle during the same period were selected as the control group (C group). Body mass index BM I), sex hormones, lipids, fasting blood glucose, fasting insulin (FINS) and insulin sensitivity index (ISI). Results ① Compared with group C, BM, I triglyceride (TG), LDL-C, FINS, LH, LH / FSH in group A (P <0.05); ISI decreased (P <0.01); ②Compared with group A, BM, ITG, LDL-C, FINS, LH, LH / FSH and T decreased <0.05); ISI increased (P <0.01). Conclusion Metformin can correct endocrine and metabolic abnormalities in PCOS patients and is an important treatment for PCOS.