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目的回顾分析乙肝病毒(HBV)感染母亲所生婴儿出生后注射乙肝免疫球蛋白(HBIG)及乙肝疫苗,对乙型肝炎母婴垂直传播的阻断效果。方法对HBV感染母亲孕期管理、产时阻断、新生儿出生后尽早注射乙肝免疫球蛋白、乙肝疫苗,婴儿进行乙肝疫苗的全程免疫,到7~12月龄釆静脉血检测乙肝血清标志物。结果 74例母亲肝功能异常者10例,正常64例。通过上述方法实施母婴阻断,所生儿童阻断成功73例(其中产生保护性抗体51例),HBV感染母亲所生儿童中感染HBV1例。结论通过正确规范实施乙肝母婴垂直传播干预措施,可有效降低HBV母婴传播的发生率。
Objective To retrospectively analyze the blocking effect of hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine on the birth of hepatitis B virus (HBV) mother and infant after birth in infants born to hepatitis B virus (HBV) infected mothers. Methods HBV infection in pregnant mothers during pregnancy management, obstruction, neonatal injection of hepatitis B immune globulin, hepatitis B vaccine as soon as possible after birth, the baby immunization of hepatitis B vaccine, to 7 to 12 months old venous blood of hepatitis B serum markers. Results 74 cases of mothers with abnormal liver function in 10 cases, normal 64 cases. Seventy-three cases were successfully blocked by mother-infant occlusion, including 51 cases of protective antibodies, and 1 case of HBV infection in children born to mothers. Conclusion By correctly regulating the intervention of vertical transmission of mother-infant hepatitis B, the incidence of mother-to-child transmission of HBV can be effectively reduced.