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阴道杀精剂应安全、方便,有效并容易被接受。但鉴于失败率较高,且必须事前短时间内使用,故其应用受限制。1973年发现心得安、氯丙嗪、酚苄明等在体外能抑制精子活动,其共同性质为具有膜稳定作用(membrane stabilising activity)。心得安之消旋混合物或右旋异构体均能抑制精子活动。鉴于右旋心得安仅具有微弱之β受体阻断作用,故心得
Vaginal spermicides should be safe, convenient, effective and easily accepted. However, its application is limited in view of its high failure rate and the need to use it in a short period of time. Amphotericin, chlorpromazine and phenoxybenzamine were found to inhibit sperm motility in vitro in 1973. Their common feature is membrane stabilizing activity. Propranolol propionate mixture or dextromer can inhibit sperm motility. In view of right-handedness Andean only weak β-blocker effect, so experience