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目的:回顾分析各种非小细胞肺癌(non-small cell lung cancer,NSCLC)的治疗方案及影响其治疗预后的因素,为合理制定个体化的综合治疗方案提供参考。方法:回顾分析近年来NSCLC治疗的研究报道,分析如病理分期、实验室检查结果(VEGF、WBC、Hg等)影响治疗预后的因素,建议相应的治疗对策。结果:1.Ⅰ期、Ⅱ期及部分Ⅲa期NSCLC的患者治疗措施首先以手术治疗为主,同步放化疗比单纯放、化疗及序贯放化疗更能有效改善晚期NSCLC的预后;2.个体相关因素、肿瘤相关因素和治疗相关因素影响NSCLC治疗预后。结论:同步放化疗在晚期NSCLC的治疗中有重要作用,肿瘤的病理分期、血浆VEGF浓度是影响NSCLC预后的独立因素。
OBJECTIVE: To retrospectively analyze the treatment regimens of various non-small cell lung cancer (NSCLC) and the factors influencing their prognosis, so as to provide a reference for the rational formulation of individualized comprehensive treatment regimens. Methods: A retrospective analysis of the reports of NSCLC treatment in recent years, analysis of factors such as pathological staging, laboratory test results (VEGF, WBC, Hg, etc.) affect the prognosis of treatment, and recommend appropriate treatment strategies. Patients with stage I, II, and some IIIa NSCLC were treated primarily with surgery. The concurrent chemoradiotherapy was more effective than simple radiotherapy, chemotherapy and sequential chemoradiotherapy in the treatment of advanced NSCLC.2. Related factors, tumor-related factors and treatment-related factors affect the prognosis of NSCLC. Conclusions: Chemotherapy with concurrent chemoradiotherapy plays an important role in the treatment of advanced non-small cell lung cancer (NSCLC). The pathological staging of tumor and plasma VEGF concentration are the independent factors influencing the prognosis of NSCLC.