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目的:分析总结儿童鱼胆中毒的原因、临床特征、救治方法和治疗效果,探讨儿童鱼胆中毒造成多器官功能损害的机制和有效治疗手段。方法:回顾分析6例儿童鱼胆中毒的原因,致病物质的毒性,患者的临床表现、实验室检查资料及治疗方法和治疗效果等。结果:6例(100%)鱼胆中毒患儿出现胃肠道症状,5例(83.3%)出现急性肾功能衰竭,5例(83.3%)出现中毒性肝炎,4例(66.6%)出现心肌受损,4例(66.6%)有神经系统表现。经过血液透析(HD)或持续静脉-静脉血液滤过(CVVH),结合其他综合治疗措施后,5例治愈,1例死亡。结论:儿童鱼胆中毒可导致多器官功能衰竭,尽早血液滤过可提高儿童鱼胆中毒的治疗效果与生存率。
OBJECTIVE: To analyze and summarize the causes, clinical characteristics, treatment methods and therapeutic effects of childhood fish gall intoxication and explore the mechanism and effective treatment of multiple organ dysfunction induced by fish gall bladder poisoning in children. Methods: Retrospective analysis of 6 cases of childhood gallbladder poisoning causes, the toxicity of pathogenic substances, the clinical manifestations of patients, laboratory tests and treatment methods and treatment effects. Results: Gastrointestinal symptoms were found in 6 cases (100%) of fish gall bladder poisoning. Acute renal failure occurred in 5 cases (83.3%), toxic hepatitis in 5 cases (83.3%) and myocardium in 4 cases (66.6% Impaired, 4 patients (66.6%) had neurological manifestations. After hemodialysis (HD) or continuous venovenous hemofiltration (CVVH), combined with other comprehensive treatment measures, 5 were cured and 1 died. Conclusion: Childhood gallbladder poisoning can lead to multiple organ failure. As soon as possible, hemofiltration can improve the therapeutic effect and survival rate of children with fish gallbladder poisoning.