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目的探讨体力活动与乳腺癌发病的关系。方法采用以医院为基础的病例对照研究,调查某大学2所附属医院2012年4月~2014年12月间确诊的25~70岁549例乳腺癌患者和同期同医院就诊的549例非肿瘤患者的体力活动情况和相关危险因素。采用非条件Logistic回归模型分析体力活动与乳腺癌发病的关系。结果校正各种混杂因素后,非职业性体力活动与乳腺癌发病风险降低有关(OR=0.69,95%CI:0.48~1.00);与不参加体育活动者相比,参加体育活动对乳腺癌发病有保护作用(OR=0.61,95%CI:0.43~0.87);与久坐不动的职业相比,轻度职业活动对乳腺癌发病有保护作用(OR=0.67,95%CI:0.47~0.97),而家务活动与乳腺癌发病风险无关。不同雌激素受体(estrogen receptor,ER)和孕激素受体(progesterone receptor,PR)状态的亚组分析中,非职业性体力活动与ER+/PR+乳腺癌的发病风险降低有关。结论非职业性体力活动、体育活动和轻度职业活动对女性乳腺癌有保护作用。
Objective To explore the relationship between physical activity and the incidence of breast cancer. Methods A hospital-based case-control study was conducted to investigate 549 breast cancer patients aged 25-70 years and 549 non-tumor patients attending the same hospital during the same period from April 2012 to December 2014 in 2 affiliated hospitals of a certain university. Physical activity and related risk factors. Non-conditional logistic regression model was used to analyze the relationship between physical activity and the incidence of breast cancer. Results After adjusting for various confounding factors, non-occupational physical activity was associated with a lower risk of developing breast cancer (OR = 0.69, 95% CI: 0.48 to 1.00). Compared with those who did not participate in physical activity, (OR = 0.67, 95% CI: 0.47 ~ 0.87). Compared with sedentary occupations, mild occupational activities had a protective effect on breast cancer (OR = 0.67,95% CI: 0.47-0.97) , While domestic activities have nothing to do with the risk of breast cancer. In a subgroup analysis of different estrogen receptor (ER) and progesterone receptor (PR) status, a decrease in the risk of non-occupational physical activity associated with ER + / PR + breast cancer. Conclusion Non-occupational physical activity, physical activity and mild occupational activity have a protective effect on female breast cancer.