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本文评价了RU486的避孕可能性,已证实黄体期中期用单次剂量能诱发妇女月经。作者试验了妊娠早期妇女黄体功能提高时,合用hCG能否诱发月经,最后直接试验药物对雌性猕猴的抗生育效果。 18名妇女,平均年龄31岁(22到41岁),平均月经周期29天(26到31天)。观察给予hCG对RU486诱发阴道出血的效果,从第一次月经周期的第3和第6天,然后从第9天起到下次月经后的第7天,每天测定血清孕酮;同时从第9天起每天测定血清LH,直到LH出现峰值,此日为黄体期的0天。18名妇女随机分为3组,每组6人。在黄体期
This article assesses the potential for contraception in RU486 and has demonstrated that menstruation can be induced by a single dose in the mid-luteal phase. The authors tested in early pregnancy women luteal function improved, combined with hCG can induce menstruation, the last direct test drug on female macaque anti-fertility. Eighteen women, mean age 31 (22 to 41 years), average 29 days (26 to 31 days) in the menstrual cycle. The effect of hCG on vaginal bleeding induced by RU486 was observed. Serum progesterone was measured every day on the 3rd and 6th day of the first menstrual cycle, then on the 9th day and the 7th day after the next menstruation. Meanwhile, Serum LH was measured daily from day 9 until the peak of LH appeared. This day was 0 day in the luteal phase. Eighteen women were randomly assigned to three groups of six. In the luteal phase