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目的探讨血浆生长停滞特异性蛋白6(Gas6)与2型糖尿病肾病早期的相关性。方法根据24 h尿微量白蛋白排泄率将105例2型糖尿病患者分为两组:正常白蛋白尿组54例、微量白蛋白尿组51例,另以30例健康人作对照组。ELISA法检测所选对象的血浆Gas6浓度;全自动生化分析仪检测尿微量白蛋白和肌酐,计算尿白蛋白/肌酐值(UACR);高效液相层析法检测糖化血红蛋白(Hb A1c)水平。结果糖尿病微量白蛋白尿组血浆Gas6浓度值M(P25,P75)为32.6 ng/ml(21.6 ng/ml~43.5 ng/ml)高于正常白蛋白尿组21.1 ng/ml(14.2 ng/ml~27.5 ng/ml)和健康对照组20.7 ng/ml(15.4 ng/ml~25.8 ng/ml),差异有统计学意义(P<0.01);正常白蛋白尿组和健康对照组Gas6浓度值差异无统计学意义(P>0.05);Gas6浓度与24 h尿微量白蛋白及Hb A1c均呈正相关(r=0.450,P<0.01;r=0.318,P<0.01)。结论 Gas6与2型糖尿病肾病微量白蛋白尿相关。
Objective To investigate the early correlation of plasma growth arrest-specific protein 6 (Gas6) with type 2 diabetic nephropathy. Methods According to the urinary albumin excretion rate of 24 hours, 105 patients with type 2 diabetes were divided into two groups: 54 in normal albuminuria group, 51 in microalbuminuria group and 30 healthy persons in control group. Plasma Gas6 concentration was measured by ELISA. Urine microalbuminuria and creatinine were measured by automatic biochemical analyzer. Urine albumin / creatinine (UACR) was calculated. HbA1c levels were determined by HPLC. Results The plasma Gas6 concentration in diabetic microalbuminuria group was 32.6 ng / ml (21.6 ng / ml ~ 43.5 ng / ml), higher than that of normal albuminuria group (21.1 ng / ml ~ 14.2 ng / ml ~ 27.5 ng / ml) and 20.7 ng / ml (15.4 ng / ml ~ 25.8 ng / ml) of the healthy control group (P <0.01). There was no significant difference between the normal albuminuria group and the healthy control group (P> 0.05). Gas6 concentration was positively correlated with 24 h urinary albumin and Hb A1c (r = 0.450, P <0.01; r = 0.318, P <0.01). Conclusion Gas6 is associated with microalbuminuria in type 2 diabetic nephropathy.