论文部分内容阅读
伏立康唑为广谱抗真菌药物,主要经肝药代谢酶CYP2C19、或CYP3A4和CYP2C9代谢,其药动学特征呈非线性并变异程度大,且该药治疗窗窄,使临床应用复杂。本研究将4项健康受试者研究和2项患者临床研究的数据(包括240名受试者的3 352个血药浓度数据)建立非线性混合效应模型分析(NONMEM),以剂量模拟检验协变量影响效应和据CYP2C19表型分层的伏立康唑浓度(2~5 mg/L)达
Voriconazole is a broad-spectrum antifungal drug, which is mainly metabolized by the hepatic drug metabolism enzymes CYP2C19, CYP3A4 and CYP2C9. The pharmacokinetic characteristics of voriconazole are nonlinear and vary greatly, and the treatment window is narrow, which makes the clinical application complicated. In this study, non-linear mixed-effects model analysis (NONMEM) was developed using data from 4 health-care and 2-patient clinical studies (including 352 plasma concentrations from 240 subjects) Variable effects and voriconazole levels (2 to 5 mg / L) stratified by CYP2C19 phenotype