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目的：评价国产氟西汀治疗抑郁障碍的疗效及副作用。方法：２２例住院抑郁障碍病人，采用随机双盲对照治疗。氟西汀组１１例（男性５例，女性６例，年龄３６±ｓ８ａ），口服氟西汀２０ｍｇ，ｑｄ；阿米替林组１１例（男性４例，女性７例，年龄３４±１３ａ），口服阿米替林７５ｍｇ，ｂｉｄ。疗程６ｗｋ。疗效及副作用分别用ＨＡＭＤ和ＴＥＳＳ评定。结果：国产氟西汀的疗效与阿米替林组相当，显效率均达９１％；而氟西汀的副作用明显较少，２组ＴＥＳＳ总分有显著差异（Ｐ＜０．０１）。结论：国产氟西汀是安全有效的抗抑郁药。
Objective: To evaluate the efficacy and side effects of domestic fluoxetine in the treatment of depression. Methods: Twenty-two inpatients with depressive disorder were randomized double-blind control. In the fluoxetine group, 11 patients (5 males, 6 females, age 36 ± s8a), oral fluoxetine 20 mg qd and amitriptyline 11 patients (4 males and 7 females, age 34 ± 13 a) , Oral amitriptyline 75mg, bid. Treatment 6wk. Efficacy and side effects were assessed by HAMD and TESS. Results: The efficacy of domestic fluoxetine was comparable to that of amitriptyline, and the effective rates were both 91%. However, the side effects of fluoxetine were significantly less, and there was significant difference between the two groups (P <0.01). Conclusion: Domestic fluoxetine is a safe and effective antidepressant.