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庆大霉素目前仍是主要的致聋抗生素,庆大霉素中毒性耳聋的发病机制包括自由基损伤学说、内耳微循环障碍学说、毛细胞线粒体功能失常学说、细胞凋亡等,并发现一些与耳聋相关的基因。聚DL-天冬氨酸(PAA)、表皮生长因子(EGF)表皮生长因子(EGF)、碱性成纤维细胞生长因子(bFGF)、神经营养因子3(NT3)、高压氧等对庆大霉素的耳毒性有一定的拮抗作用。中医药丹参、天鼓冲剂、复聪片、耳聋左慈丸等也可减轻庆大霉素的耳毒性。庆大霉素中毒性耳聋基因治疗具有良好的前景。制造一种由病毒DNA序列和非病毒载体结构共同组成的复合型载体,也许是未来基因治疗载体得到完善、基因治疗得到突破性进展的着手点之一。
Gentamicin is still the main deafness antibiotic. The pathogenesis of gentamicin toxic deafness includes the theory of free radical damage, the theory of microcirculation in the inner ear, the theory of hair cell mitochondrial dysfunction, apoptosis and so on, and some Deafness-related genes. Polyglutamic acid (PAA), epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), neurotrophic factor 3 (NT3) Suffering from ototoxicity has some antagonism. Chinese medicine Salvia, tiankang granules, Fucong tablets, deafness Zuo Ci pills can also reduce gentamicin ototoxicity. Gentamicin toxic deafness gene therapy has a good prospect. To create a complex vector composed of viral DNA sequences and non-viral vector structures may be one of the starting points for the future improvement of gene therapy vectors and the breakthrough in gene therapy.