皮质类固醇对哮喘的治疗有无可怀疑的价值,但长期使用能引起肾上腺抑制。本文研究了试用丙酮化氟羟强的松龙(Triamcinolone Acetonide)气雾剂治疗支气管哮喘,以争取能产生较大的疗效而又能避免副作用。丙酮化氟羟强的松龙是一种无极性的、不溶于水的皮质类固醇,可以在不引起身体吸收的情况下起作用。它被制成一种冰冻气雾剂,通过一个适应器释放到呼吸道,以最大限度减少在口腔的沉着。百分之九十的微粒直径小于5微米,气雾剂一次喷射约50微克的药物到呼吸道。对正常人的研究表明每天2毫克药物分4次给药,每次吸入10次,不影响血浆氢化可的 Corticosteroids for the treatment of asthma have no doubt that the value, but long-term use can cause adrenal suppression. This article studies the trial of triamcinolone acetonide aerosol for the treatment of bronchial asthma in an effort to achieve greater efficacy and avoid side effects. Acetophenone is a nonpolar, water-insoluble corticosteroid that works without causing body absorption. It is made into a frozen aerosol that is released into the respiratory tract through a single adapter to minimize sedation in the mouth. Ninety percent of the particles are less than 5 microns in diameter and the aerosol sprays about 50 micrograms of drug into the respiratory tract at once. Studies of normal subjects show that 2 mg of the drug is administered 4 times a day, 10 times per inhalation, without affecting plasma hydrogenation