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目的:观察参芪地黄汤联合克龄蒙治疗肾阴虚型卵巢早衰(POF)的临床疗效。方法:将80例肾阴虚型POF患者随机分为治疗组和对照组各40例。对照组给予克龄蒙治疗,治疗组在对照组用药基础上加用参芪地黄汤。2组均治疗3个月经周期。观察2组临床症状、体征的改善情况,及2组治疗前后血清促卵泡生成激素(FSH)、雌二醇(E2)水平的变化;比较2组复发率。结果:对照组总有效率72.5%,治疗组总有效率90.0%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组血清FSH水平均较治疗前降低(P<0.01),E2水平均较治疗前升高(P<0.01);观察组的FSH水平较对照组下降更明显(P<0.01);E2水平较对照组上升更明显(P<0.01)。对照组复发率51.7%,治疗组复发率8.3%,2组比较,差异有统计学意义(P<0.01)。结论:参芪地黄汤联合克龄蒙治疗肾阴虚型POF,可有效改善患者的临床症状、体征及血清FSH、E2水平,效果优于单纯使用克龄蒙,值得临床借鉴。
Objective: To observe the clinical efficacy of Shenqi Dihuang Decoction combined with Kelmung on treating premature ovarian failure (POF) with deficiency of kidney yin. Methods: Eighty POF patients with deficiency of kidney yin were randomly divided into treatment group (40 cases) and control group (40 cases). The control group was given gram of Mongolian treatment, the treatment group in the control group based on the use of Shen Qi Di Huang Tang. 2 groups were treated 3 menstrual cycle. The clinical symptoms and signs of the two groups were observed and the changes of serum follicle-stimulating hormone (FSH) and estradiol (E2) in the two groups before and after treatment were observed. The recurrence rate was compared between the two groups. Results: The total effective rate was 72.5% in the control group and 90.0% in the treatment group. There was significant difference between the two groups (P <0.05). After treatment, FSH levels in both groups were significantly lower than those before treatment (P <0.01), and E2 levels were significantly higher than those before treatment (P <0.01). FSH levels in the observation group were significantly lower than those in the control group (P <0.01). E2 levels increased more significantly than the control group (P <0.01). The recurrence rate was 51.7% in the control group and 8.3% in the treatment group. There was significant difference between the two groups (P <0.01). Conclusion: Shenqi Dihuang Decoction combined with Kelmian treatment of POF of kidney yin deficiency can effectively improve the clinical symptoms, signs and serum FSH, E2 levels, the effect is better than the simple use of gram Ling, is worthy of clinical reference.